Nanoscale Changes on RBC Membrane Induced by Storage and Ionizing Radiation: A Mini-Review

Andrea M. López-Canizales, Aracely Angulo-Molina*, Adriana Garibay-Escobar, Erika Silva-Campa, Miguel A. Mendez-Rojas, Karla Santacruz-Gómez, Mónica Acosta-Elías, Beatriz Castañeda-Medina, Diego Soto-Puebla, Osiris Álvarez-Bajo, Alexel Burgara-Estrella, Martín Pedroza-Montero*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

6 Citas (Scopus)


The storage lesions and the irradiation of blood cellular components for medical procedures in blood banks are events that may induce nanochanges in the membrane of red blood cells (RBCs). Alterations, such as the formation of pores and vesicles, reduce flexibility and compromise the overall erythrocyte integrity. This review discusses the alterations on erythrocytic lipid membrane bilayer through their characterization by confocal scanning microscopy, Raman, scanning electron microscopy, and atomic force microscopy techniques. The interrelated experimental results may address and shed light on the correlation of biomechanical and biochemical transformations induced in the membrane and cytoskeleton of stored and gamma-irradiated RBC. To highlight the main advantages of combining these experimental techniques simultaneously or sequentially, we discuss how those outcomes observed at micro- and nanoscale cell levels are useful as biomarkers of cell aging and storage damage.

Idioma originalInglés
Número de artículo669455
PublicaciónFrontiers in Physiology
EstadoPublicada - 4 jun. 2021

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© Copyright © 2021 López-Canizales, Angulo-Molina, Garibay-Escobar, Silva-Campa, Mendez-Rojas, Santacruz-Gómez, Acosta-Elías, Castañeda-Medina, Soto-Puebla, Álvarez-Bajo, Burgara-Estrella and Pedroza-Montero.


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