Optimization of Carvacrol Nanoemulsion for the Incorporation in Pectin Membranes: Influence on Their Load Capacity, Microstructure and Antibacterial Properties

O. Beltrán, M. Luna, E. Valbuena-Gregorio, R. G. Valdez-Melchor, S. E. Burruel-Ibarra, L. Quihui-Cota, S. Ruiz-Cruz, J. Juárez, M. A. López-Mata*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Interest in developing novel wound dressings with antibacterial properties elaborated from natural sources continues to grow. In this study, a Tween-80 (T80)-stabilized carvacrol (CAR) emulsion was incorporated into pectin (PEC) membranes at 0 (control), 0.25, 0.50, and 1.00% (v/v). Membranes were obtained by the dry-casting method, characterized by scanning electron microscopy, infrared spectroscopy, and CAR retention (HPLC), and tested for antibacterial activity. The retention percentage of CAR in the membranes ranged from 9.1-13.9%. Infrared spectra analysis indicated changes in the hydrogen bonds of the membranes that suggest an interaction between the polymer matrix and the CAR:T80 emulsion. Microstructural analysis of the membranes showed the presence of hole-like features on the surface (≈ 4-6 μm diameter) that indicate entrapment of the micelles in the matrix (microcapsules). The PEC-CAR membranes exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus, two pathogens commonly associated with wounds and intra-hospital infections.

Idioma originalInglés
Número de artículoe20210534
PublicaciónMaterials Research
Volumen25
DOI
EstadoPublicada - 2022

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© 2022 Universidade Federal de Sao Carlos. All rights reserved.

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