Phenolic compounds that cross the blood-brain barrier exert positive health effects as central nervous system antioxidants

Dafne Velásquez-Jiménez, Diana A. Corella-Salazar, B. Shain Zuñiga-Martínez, J. Abraham Domínguez-Avila*, Marcelino Montiel-Herrera, Norma J. Salazar-López, Joaquín Rodrigo-Garcia, Mónica A. Villegas-Ochoa, Gustavo A. González-Aguilar

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

13 Citas (Scopus)

Resumen

The blood-brain barrier (BBB) is a physical structure whose main function is to strictly regulate access to circulating compounds into the central nervous system (CNS). Vegetable-derived phenolic compounds have been widely studied, with numerous epidemiologic and interventional studies confirming their health-related bioactivities across multiple cells, organs and models. Phenolics are non-essential xenobiotics, and should theoretically be unable to cross the BBB. The present work summarizes current experimental evidence that reveals that not only are phenolic compounds able to cross the BBB and bioaccumulate in the brain, but there is some stereoselectivity, which suggests the presence of specific transporters that allow them to reach the brain. Some molecules cross the BBB intact, while others do so only after being biotransformed or metabolized elsewhere. Once inside the CNS, they prevent or counter oxidative stress, which maintains the molecular, cellular, structural and functional integrity of the brain, and subsequently, overall human health.

Idioma originalInglés
Páginas (desde-hasta)10356-10369
Número de páginas14
PublicaciónFood and Function
Volumen12
N.º21
DOI
EstadoPublicada - 7 nov 2021

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© 2021 The Royal Society of Chemistry.

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