Phosphatase-triggered guest release from a cyclodextrin complex

Cho Arthur; Karen L. Ochoa Lara; Anatoly K. Yatsimirsky; Alexey V. Eliseev

doi:10.1021/ol005915x

Phosphatase-triggered guest release from a cyclodextrin complex

Cho Arthur, Karen L. Ochoa Lara, Anatoly K. Yatsimirsky^*, Alexey V. Eliseev

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

21 Citas (Scopus)

Resumen

(matrix presented) A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. β-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native β-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.

Idioma original	Inglés
Páginas (desde-hasta)	1741-1743
Número de páginas	3
Publicación	Organic Letters
Volumen	2
N.º	12
DOI	https://doi.org/10.1021/ol005915x
Estado	Publicada - 15 jun. 2000
Publicado de forma externa	Sí

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abstract = "(matrix presented) A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. β-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native β-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.",

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AU - Arthur, Cho

AU - Ochoa Lara, Karen L.

AU - Yatsimirsky, Anatoly K.

AU - Eliseev, Alexey V.

PY - 2000/6/15

Y1 - 2000/6/15

N2 - (matrix presented) A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. β-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native β-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.

AB - (matrix presented) A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. β-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native β-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.

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U2 - 10.1021/ol005915x

DO - 10.1021/ol005915x

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JO - Organic Letters

JF - Organic Letters

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ER -

Phosphatase-triggered guest release from a cyclodextrin complex

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