Poly(lactic-co-glycolic acid) nanoparticles for sustained release of allyl isothiocyanate: characterization, in vitro release and biological activity

David Encinas-Basurto, Jaime Ibarra, Josué Juarez, María G. Burboa, Silvia Barbosa, Pablo Taboada, Rosalba Troncoso-Rojas, Miguel A. Valdez*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

24 Citas (Scopus)

Resumen

The objective of this study is to establish the ability of entrap allyl isothiocyanate (AITC) into polymeric nanoparticles to extend its shelf life and enhance its antiproliferative properties. Natural compounds, such as AITC, have showed multi-targeting activity resulting in a wide-range spectrum of therapeutic properties in chronic and degenerative diseases, conversely with most current pharmaceutical drugs showing single targeting activity and often result in drug resistance after extended administration periods. Apparently, AITC-loaded poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) reduced AITC degradation and volatility and were able to extend AITC shelf life compared with free AITC (65% vs. 20% in 24 h, respectively). Cell viability and uptake of AITC-loaded nanoparticles were studied in vitro, showing that the protection and sustained release of AITC from polymeric NPs involved a larger toxicity of tumoral cells. These nanoparticles could be used as protective systems for enhancing a biological activity.

Idioma originalInglés
Páginas (desde-hasta)231-242
Número de páginas12
PublicaciónJournal of Microencapsulation
Volumen34
N.º3
DOI
EstadoPublicada - 3 abr. 2017

Nota bibliográfica

Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.

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