TY - JOUR
T1 - Polyurethane electrospun membranes with hydroxyapatite-vancomycin for potential application in bone tissue engineering and drug delivery
AU - Vásquez-López, Claudia
AU - Castillo-Ortega, Maria Monica
AU - Chan-Chan, Lerma Hanaiy
AU - Lagarda-Díaz, Irlanda
AU - Giraldo-Betancur, Astrid Lorena
AU - Rodríguez Félix, Dora Evelia
AU - Encinas-Encinas, Jose Carmelo
AU - Martínez-Barbosa, Maria Elisa
AU - Cadenas-Pliego, Gregorio
AU - Cauich-Rodríguez, Juan Valerio
AU - Herrera-Franco, Pedro Jesus
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2022/4/10
Y1 - 2022/4/10
N2 - The purpose of this study is to evaluate the drug delivery behavior and other properties of electrospun composite membranes for potential use in tissue engineering. Tecoflex® (PU1), and a lab-made polyurethane (PU2) were studied. They were mixed with nano-hydroxyapatite (PU1-nHA and PU2-nHA) and vancomycin (PU1-VA and PU2-VA) or mixed with both, nHA and VA (PU1-nHA-VA and PU2-nHA-VA). Scanning electron microscopy showed a porous structure in all the electrospun membranes with smooth fibers in PU1 and its composites with sizes in the range of 0.6–0.9 μm and nanoparticles of HA, both, adhered and embedded on the PU fibers were observed. nHA and VA affected the thermal and mechanical behavior of composites. Elastic modulus, cytotoxicity, and kinetic release were affected by the PU and nHA. Cell viability up to 75% showed that all membrane extracts are not cytotoxic while microbial inhibition activity was observed in PU1-VA, PU1-nHA-VA, and PU2-VA.
AB - The purpose of this study is to evaluate the drug delivery behavior and other properties of electrospun composite membranes for potential use in tissue engineering. Tecoflex® (PU1), and a lab-made polyurethane (PU2) were studied. They were mixed with nano-hydroxyapatite (PU1-nHA and PU2-nHA) and vancomycin (PU1-VA and PU2-VA) or mixed with both, nHA and VA (PU1-nHA-VA and PU2-nHA-VA). Scanning electron microscopy showed a porous structure in all the electrospun membranes with smooth fibers in PU1 and its composites with sizes in the range of 0.6–0.9 μm and nanoparticles of HA, both, adhered and embedded on the PU fibers were observed. nHA and VA affected the thermal and mechanical behavior of composites. Elastic modulus, cytotoxicity, and kinetic release were affected by the PU and nHA. Cell viability up to 75% showed that all membrane extracts are not cytotoxic while microbial inhibition activity was observed in PU1-VA, PU1-nHA-VA, and PU2-VA.
UR - http://www.scopus.com/inward/record.url?scp=85118916896&partnerID=8YFLogxK
U2 - 10.1002/app.51893
DO - 10.1002/app.51893
M3 - Artículo
AN - SCOPUS:85118916896
SN - 0021-8995
VL - 139
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 14
M1 - 51893
ER -