TY - JOUR
T1 - Potencial antioxidante, antihemólisis y retinoprotectorr de compuestos lipídicos bioactivos provenientes del músculo del camarón salvaje (Litopenaeus stylirostris)
AU - García-Romo, Joel Said
AU - Noguera-Artiaga, Luis
AU - Gálvez-Iriqui, Alma Carolina
AU - Hernández-Zazueta, Martin Samuel
AU - Valenzuela-Cota, Daniel Fernando
AU - González-Vega, Ricardo Iván
AU - Plascencia-Jatomea, Maribel
AU - Burboa-Zazueta, María Guadalupe
AU - Sandoval-Petris, Edgar
AU - Robles-Sánchez, Rosario Maribel
AU - Juárez, Josué
AU - Hernández-Martínez, Javier
AU - Santacruz-Ortega, Hisila del Carmen
AU - Burgos-Hernández, Armando
N1 - Publisher Copyright:
© 2020, © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - The oxidative stress damage on cells is an example of roles in the pathogenesis of different degenerative diseases and the search of compounds that can slow this oxidation is continuous. The aim of this work was to obtain bioactive fractions from wild shrimp (Litopenaeus stylirostris) muscle, in order to evaluate their protective capacity and chemo-structurally characterize them. ABTS and DPPH, and FRAP assays suggested that bioactive fractions possess free radical-scavenging capacity, and reducing power, respectively. An inhibitory effect observed on AAPH-induced hemolysis and results from an H2O2-derived radicals-scavenging assay (retinoprotective) suggest that these fractions can exert their protective activity in human cells. UV–Vis, fluorescence, 13C-, 1H-NMR, and ESI-MS studies performed on the most bioactive fraction, suggests that their main components are eicosapentaenoic acid, dioctyl phthalate, and a possibly novel indolocarbazole alkaloid derivative. These results suggest that these compounds are good candidates to further investigations as possible chemoprotective agents.
AB - The oxidative stress damage on cells is an example of roles in the pathogenesis of different degenerative diseases and the search of compounds that can slow this oxidation is continuous. The aim of this work was to obtain bioactive fractions from wild shrimp (Litopenaeus stylirostris) muscle, in order to evaluate their protective capacity and chemo-structurally characterize them. ABTS and DPPH, and FRAP assays suggested that bioactive fractions possess free radical-scavenging capacity, and reducing power, respectively. An inhibitory effect observed on AAPH-induced hemolysis and results from an H2O2-derived radicals-scavenging assay (retinoprotective) suggest that these fractions can exert their protective activity in human cells. UV–Vis, fluorescence, 13C-, 1H-NMR, and ESI-MS studies performed on the most bioactive fraction, suggests that their main components are eicosapentaenoic acid, dioctyl phthalate, and a possibly novel indolocarbazole alkaloid derivative. These results suggest that these compounds are good candidates to further investigations as possible chemoprotective agents.
KW - antioxidant activity
KW - chemoprevention
KW - hemolysis
KW - Protective activity
KW - ROS scavenger
UR - http://www.scopus.com/inward/record.url?scp=85080140193&partnerID=8YFLogxK
U2 - 10.1080/19476337.2020.1719210
DO - 10.1080/19476337.2020.1719210
M3 - Artículo
AN - SCOPUS:85080140193
SN - 1947-6337
VL - 18
SP - 153
EP - 163
JO - CYTA - Journal of Food
JF - CYTA - Journal of Food
IS - 1
ER -