Pregnancy Differentially Regulates the Collagens Types i and III in Left Ventricle from Rat Heart

Sarai Limon-Miranda, Diana G. Salazar-Enriquez, Jesus Muñiz, Mario V. Ramirez-Archila, Enrique A. Sanchez-Pastor, Felipa Andrade, Jose G. Soñanez-Organis, Edgar F. Moran-Palacio, Adolfo Virgen-Ortiz*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

The pathologic cardiac remodeling has been widely documented; however, the physiological cardiac remodeling induced by pregnancy and its reversion in postpartum are poorly understood. In the present study we investigated the changes in collagen I (Col I) and collagen III (Col III) mRNA and protein levels in left ventricle from rat heart during pregnancy and postpartum. Col I and Col III mRNA expression in left ventricle samples during pregnancy and postpartum were analyzed by using quantitative PCR. Data obtained from gene expression show that Col I and Col III in left ventricle are upregulated during pregnancy with reversion in postpartum. In contrast to gene expression, the protein expression evaluated by western blot showed that Col I is downregulated and Col III is upregulated in left ventricle during pregnancy. In conclusion, the pregnancy differentially regulates collagens types I and III in heart; this finding could be an important molecular mechanism that regulates the ventricular stiffness in response to blood volume overload present during pregnancy which is reversed in postpartum.

Idioma originalInglés
Número de artículo984785
PublicaciónBioMed Research International
Volumen2014
DOI
EstadoPublicada - 2014

Nota bibliográfica

Publisher Copyright:
© 2014 Sarai Limon-Miranda et al.

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