TY - JOUR
T1 - Preparation by coaxial electrospinning and characterization of membranes releasing (-) epicatechin as scaffold for tissue engineering
AU - Castillo-Ortega, M. M.
AU - Montaño-Figueroa, A. G.
AU - Rodríguez-Félix, D. E.
AU - Prado-Villegas, G.
AU - Pino-Ocaño, K. P.
AU - Valencia-Córdova, M. J.
AU - Quiroz-Castillo, J. M.
AU - Herrera-Franco, P. J.
N1 - Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Optimal conditions for the preparation of a composite material of fibers of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP), containing epicatechin (Epic) within the fiber CA/PVP-Epic/CA, were found. The morphology and physical/chemical properties of the fibrous membranes containing CA, PVP, and epicatechin were characterized using FTIR spectroscopy, thermal analysis, SEM, TEM, and natural weathering. Also, mechanical characterization of the fibers showed that tensile strength of the membrane was not affected by the presence of epicatechin within the fiber as compared with fibers without epicatechin. The effect of the medium on the release rate of epicatechin was also studied. The amount of epicatechin release was higher in water, 79.6%, and 31% in MesenCult medium. These results showed that these composite materials are recommended for cardiac tissue engineering; furthermore, using these materials allows precise release of the epicatechin in the damaged tissue.
AB - Optimal conditions for the preparation of a composite material of fibers of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP), containing epicatechin (Epic) within the fiber CA/PVP-Epic/CA, were found. The morphology and physical/chemical properties of the fibrous membranes containing CA, PVP, and epicatechin were characterized using FTIR spectroscopy, thermal analysis, SEM, TEM, and natural weathering. Also, mechanical characterization of the fibers showed that tensile strength of the membrane was not affected by the presence of epicatechin within the fiber as compared with fibers without epicatechin. The effect of the medium on the release rate of epicatechin was also studied. The amount of epicatechin release was higher in water, 79.6%, and 31% in MesenCult medium. These results showed that these composite materials are recommended for cardiac tissue engineering; furthermore, using these materials allows precise release of the epicatechin in the damaged tissue.
KW - Drug delivery
KW - Electrospinning
KW - Epicatechin
KW - Fiber
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84908322132&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2014.10.031
DO - 10.1016/j.msec.2014.10.031
M3 - Artículo
SN - 0928-4931
VL - 46
SP - 184
EP - 189
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -