Prevalent HLA class II alleles in Mexico City appear to confer resistance to the development of amebic liver abscess

Eric G. Hernández, Julio Granados, Oswaldo Partida-Rodríguez, Olivia Valenzuela, Edgar Rascón, Ulises Magaña, Mónica Escamilla-Tilch, Alberto López-Reyes, Miriam Nieves-Ramírez, Enrique González, Patricia Morán, Liliana Rojas, Alicia Valadez, Alexandra Luna, Francisco J. Estrada, Carmen Maldonado, Cecilia Ximénez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

Amebiasis is an endemic disease and a public health problem throughout Mexico, although the incidence rates of amebic liver abscess (ALA) vary among the geographic regions of the country. Notably, incidence rates are high in the northwestern states (especially Sonora with a rate of 12.57/100,000 inhabitants) compared with the central region (Mexico City with a rate of 0.69/100,000 inhabitants). These data may be related to host genetic factors that are partially responsible for resistance or susceptibility. Therefore, we studied the association of the HLA-DRB1 and HLA-DQB1 alleles with resistance or susceptibility to ALA in two Mexican populations, one each from Mexico City and Sonora. Ninety ALA patients were clinically diagnosed by serology and sonography. Genomic DNA was extracted from peripheral blood mononuclear cells. To establish the genetic identity of both populations, 15 short tandem repeats (STRs) were analyzed with multiplexed PCR, and the allelic frequencies of HLA were studied by PCR-SSO using LUMINEX technology. The allele frequencies obtained were compared to an ethnically matched healthy control group (146 individuals). We observed that both affected populations differed genetically from the control group. We also found interesting trends in the population from Mexico City. HLA-DQB1∗02 allele frequencies were higher in ALA patients compared to the control group (0.127 vs 0.047; p= 0.01; pc= NS; OR= 2.9, 95% CI= 1.09-8.3). The less frequent alleles in ALA patients were HLADRB1∗08 (0.118 vs 0.238 in controls; p= 0.01; pc= NS; OR= 0.42, 95% CI= 0.19-0.87) and HLA-DQB1∗04 (0.109 vs 0.214; p= 0.02; pc= NS; OR= 0.40, 95% CI= 0.20-0.94). The haplotype HLA-DRB1∗08/-DQB1∗04 also demonstrated a protective trend against the development of this disease (0.081 vs. 0.178; p=0.02; pc=NS; OR= 0.40, 95% CI= 0.16-0.93). These trends suggest that the prevalent alleles in the population of Mexico City may be associated with protection against the development of ALA.

Idioma originalInglés
Número de artículoe0126195
PublicaciónPLoS ONE
Volumen10
N.º5
DOI
EstadoPublicada - 4 may. 2015

Nota bibliográfica

Publisher Copyright:
© 2015 Hernández et al.

Huella

Profundice en los temas de investigación de 'Prevalent HLA class II alleles in Mexico City appear to confer resistance to the development of amebic liver abscess'. En conjunto forman una huella única.

Citar esto