Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)

G. Ruiz-Montañez, A. Burgos-Hernández, M. Calderón-Santoyo*, C. M. López-Saiz, C. A. Velázquez-Contreras, A. Navarro-Ocaña, J. A. Ragazzo-Sánchez

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

30 Citas (Scopus)

Resumen

The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.

Idioma originalInglés
Páginas (desde-hasta)409-416
Número de páginas8
PublicaciónFood Chemistry
Volumen175
DOI
EstadoPublicada - 15 may. 2015

Nota bibliográfica

Publisher Copyright:
© 2014 Elsevier Ltd.

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