TY - JOUR
T1 - Seasonal effect on chemical composition and biological activities of Sonoran propolis
AU - Valencia, Dora
AU - Alday, Efrain
AU - Robles-Zepeda, Ramon
AU - Garibay-Escobar, Adriana
AU - Galvez-Ruiz, Juan C.
AU - Salas-Reyes, Magali
AU - Jiménez-Estrada, Manuel
AU - Velazquez-Contreras, Enrique
AU - Hernandez, Javier
AU - Velazquez, Carlos
N1 - Funding Information:
We thank professional beekeeper Gilberto Valenzuela for all facilities provided for propolis collection. We are grateful to Karla Martinez Robinson for technical support of this research. This work was partially supported by a Grant from National Council for Science and Technology of Mexico (CONACYT, 83462 ).
PY - 2012/3/15
Y1 - 2012/3/15
N2 - Propolis is widely used as a folk medicine and as a constituent of health foods in many parts of the world. The main purpose of this study was to evaluate the seasonal effect on the chemical composition and biological activities (antiproliferative and antioxidant activities) of Sonoran propolis (Mexico). Propolis was collected during all four seasons of the year and chemical composition, antiproliferative, and free-radical scavenging activities of collected propolis were evaluated by HPLC, MTT, and DPPH assays, respectively. The relative abundance of the main chemical constituents of propolis was similar in all propolis samples analysed. In contrast, significant differences were observed in their antiproliferative activity in the B-cell lymphoma cancer cell line M12.C3.F6. Propolis collected in the spring showed the highest inhibitory effect on the growth of cancer cells. All propolis samples had weak free-radical scavenging activity. Our results indicate that season had a significant effect on the antiproliferative properties of Sonoran propolis.
AB - Propolis is widely used as a folk medicine and as a constituent of health foods in many parts of the world. The main purpose of this study was to evaluate the seasonal effect on the chemical composition and biological activities (antiproliferative and antioxidant activities) of Sonoran propolis (Mexico). Propolis was collected during all four seasons of the year and chemical composition, antiproliferative, and free-radical scavenging activities of collected propolis were evaluated by HPLC, MTT, and DPPH assays, respectively. The relative abundance of the main chemical constituents of propolis was similar in all propolis samples analysed. In contrast, significant differences were observed in their antiproliferative activity in the B-cell lymphoma cancer cell line M12.C3.F6. Propolis collected in the spring showed the highest inhibitory effect on the growth of cancer cells. All propolis samples had weak free-radical scavenging activity. Our results indicate that season had a significant effect on the antiproliferative properties of Sonoran propolis.
KW - Antiproliferative activity
KW - Chemical composition
KW - Seasonal effect
KW - Sonoran propolis
UR - http://www.scopus.com/inward/record.url?scp=80054965075&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2011.08.086
DO - 10.1016/j.foodchem.2011.08.086
M3 - Artículo
SN - 0308-8146
VL - 131
SP - 645
EP - 651
JO - Food Chemistry
JF - Food Chemistry
IS - 2
ER -