Seasonal Effect on the Biological Activities of Litsea glaucescens Kunth Extracts

Julio César López-Romero, Humberto González-Ríos, Aida Peña-Ramos, Carlos Velazquez, Moises Navarro, Ramón Robles-Zepeda, Evelin Martínez-Benavidez, Inocencio Higuera-Ciapara, Claudia Virués, José Luis Olivares, Zaira Domínguez*, Javier Hernández

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

19 Citas (Scopus)

Resumen

This study shows the seasonal effect on the antioxidant, antiproliferative, and antimicrobial activities of L. glaucescens Kunth (LG) leaves extracts. Their antioxidant activity was evaluated through the DPPH, FRAP, and ORAC assays. Their phenolic content (PC) was determined by means of the Folin-Ciocalteu method, and the main phenolic compounds were identified through a HPLC-DAD analysis. Antiproliferative activity was determined by MTT assay against HeLa, LS 180, M12.C3.F6, and ARPE cell lines. Antimicrobial potential was evaluated against Staphylococcus aureus and Escherichia coli using a microdilution method. All the LG extracts presented high antioxidant activity and PC, with quercitrin and epicatechin being the most abundant. Antioxidant activity and PC were affected by the season; particularly autumn (ALGE) and summer (SULGE) extracts exhibited the highest values (p<0.05). All extracts presented moderate antiproliferative activity against the cell lines evaluated, HeLa being the most susceptible of them. However, ALGE and SULGE were the most active too. About antimicrobial activity, SULGE (MIC90<800 μg/mL; MIC 50 < 400 μg/mL), and SLGE (MIC 50 < 1000 μg/mL) showed a moderate inhibitory effect against S. aureus. These findings provide new information about the seasonal effect on the PC and biological properties of LG extracts. Clearly, antioxidant activity was the most important with respect to the other two.

Idioma originalInglés
Número de artículo2738489
PublicaciónEvidence-based Complementary and Alternative Medicine
Volumen2018
DOI
EstadoPublicada - 2018

Nota bibliográfica

Publisher Copyright:
© 2018 Julio César López-Romero et al.

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