TY - JOUR
T1 - Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum
AU - Urrea-Quezada, Alejandro
AU - Balmaceda-Baca, Ruben
AU - Garibay, Adriana
AU - Hernández, Jesús
AU - Valenzuela, Olivia
N1 - Publisher Copyright:
Copyright © 2022 Urrea-Quezada, Balmaceda-Baca, Garibay, Hernández and Valenzuela.
PY - 2022/1/19
Y1 - 2022/1/19
N2 - Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.
AB - Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.
KW - IgG
KW - emerging parasites
KW - human cryptosporidiosis
KW - humoral response
KW - synthetic peptides
UR - http://www.scopus.com/inward/record.url?scp=85124035316&partnerID=8YFLogxK
U2 - 10.3389/fcimb.2021.810887
DO - 10.3389/fcimb.2021.810887
M3 - Artículo
C2 - 35127561
AN - SCOPUS:85124035316
SN - 2235-2988
VL - 11
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 810887
ER -