TY - JOUR
T1 - Sonoran propolis
T2 - Chemical composition and antiproliferative activity on cancer cell lines
AU - Hernandez, Javier
AU - Goycoolea, Francisco M.
AU - Quintero, Jael
AU - Acosta, Ana
AU - Castañeda, Marco
AU - Dominguez, Zaira
AU - Robles, Refugio
AU - Vazquez-Moreno, Luz
AU - Velazquez, Enrique F.
AU - Astiazaran, Humberto
AU - Lugo, Efraín
AU - Velazquez, Carlos
PY - 2007/11
Y1 - 2007/11
N2 - In this study, we have analyzed the chemical composition and antiproliferative activity of propolis from three different arid and semiarid regions of Sonora, Mexico. We identified and quantitated the main chemical constituents of propolis by HPLC-MS. The most abundant constituents of propolis were pinocembrin, pinobanksin 3-acetate, and chrysin. Sonoran propolis had a strong antiproliferative activity on both murine and human cancer cell lines in a concentration-dependent manner. The propolis constituents CAPE, galangin, xanthomicrol and chrysin showed significant antiproliferative activity on most of the cancer cells tested. DNA harvested from cancer cell cultures treated with Sonoran propolis exhibited a ladder of internucleosomal DNA cleavage characteristic of apoptosis. In summary, we have identified and quantitated the main constituents of Sonoran propolis. These propolis samples possess a strong antiproliferative activity on cancer cell lines.
AB - In this study, we have analyzed the chemical composition and antiproliferative activity of propolis from three different arid and semiarid regions of Sonora, Mexico. We identified and quantitated the main chemical constituents of propolis by HPLC-MS. The most abundant constituents of propolis were pinocembrin, pinobanksin 3-acetate, and chrysin. Sonoran propolis had a strong antiproliferative activity on both murine and human cancer cell lines in a concentration-dependent manner. The propolis constituents CAPE, galangin, xanthomicrol and chrysin showed significant antiproliferative activity on most of the cancer cells tested. DNA harvested from cancer cell cultures treated with Sonoran propolis exhibited a ladder of internucleosomal DNA cleavage characteristic of apoptosis. In summary, we have identified and quantitated the main constituents of Sonoran propolis. These propolis samples possess a strong antiproliferative activity on cancer cell lines.
KW - Antiproliferative activity
KW - Chemical composition
KW - Sonoran propolis
UR - http://www.scopus.com/inward/record.url?scp=36949016040&partnerID=8YFLogxK
U2 - 10.1055/s-2007-990244
DO - 10.1055/s-2007-990244
M3 - Artículo
SN - 0032-0943
VL - 73
SP - 1469
EP - 1474
JO - Planta Medica
JF - Planta Medica
IS - 14
ER -