Study of Electrospun Membranes Composed of PCL and Tilapia-Skin Collagen with Tetracycline or Chloramphenicol in Contact with Human Skin Fibroblasts for Wound Dressing Treatment

Abraham Alejandro Leyva-Verduzco, Jesús Manuel Quiroz Castillo*, Lerma Hanaiy Chan-Chan, Claudia Georgina Ramirez-Mendoza, María Mónica Castillo Ortega, Damián Francisco Plascencia-Martínez, Itzel Yanira López-Peña, Celia Olivia García-Sifuentes

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Diabetic foot ulcers are a common complication of diabetes mellitus and can lead to severe infections and delayed wound healing. The development of effective wound dressings is crucial to promoting faster healing and preventing infections. This investigation aims to fabricate and characterize electrospun meshes composed of poly(ϵ-caprolactone) and collagen, extracted from tilapia skin. Additionally, tetracycline and chloramphenicol were incorporated into the dressings to explore their potential to combat wound infections. A comprehensive characterization was carried out, covering the physical structure, chemical composition, and potential application-related properties of the materials by the combination of scanning electron microscopy, Fourier transform infrared (FTIR), mechanical analysis, cell viability, live/dead staining, and microbiological analysis. Changes in mechanical properties were observed, related to the morphology of the membranes; the presence of the active molecules is evidenced by FTIR analysis; cell viability above control was observed for all the prepared membranes, and they were active in antimicrobial tests, suggesting that the developed materials have the potential to be further explored as wound dressings or scaffolds for diabetic foot ulcers.

Idioma originalInglés
Páginas (desde-hasta)5361-5370
Número de páginas10
PublicaciónACS Omega
Volumen9
N.º5
DOI
EstadoPublicada - 6 feb. 2024

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Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society

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