Synthesis and characterization of a bioconjugate based on oleic acid and l-cysteine

Paul Zavala Rivera*, Jesús Armando Lucero Acuña, Ricardo López Esparza, Daniel Fernández-Quiroz, Marco Vizcarra-Pacheco, Maria Ley-Flores, Ana Mizrahim Matrecitos-Burruel

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)


One of the main challenges facing materials science today is the synthesis of new biodegradable and biocompatible materials capable of improving existing ones. This work focused on the synthesis of new biomaterials from the bioconjugation of oleic acid with L-cysteine using carbodi-imide. The resulting reaction leads to amide bonds between the carboxylic acid of oleic acid and the primary amine of L-cysteine. The formation of the bioconjugate was corroborated by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and nuclear magnetic resonance (NMR). In these techniques, the development of new materials with marked differences with the precursors was confirmed. Furthermore, NMR has elucidated a surfactant structure, with a hydrophilic part and a hydrophobic section. Ultraviolet-visible spectroscopy (UV-Vis) was used to determine the critical micellar concentration (CMC) of the bioconjugate. Subsequently, light diffraction (DLS) was used to analyze the size of the resulting self-assembled structures. Finally, transmission electron microscopy (TEM) was obtained, where the shape and size of the self-assembled structures were appreciated.

Idioma originalInglés
Número de artículo1791
Páginas (desde-hasta)1791
EstadoPublicada - 1 jun. 2021

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


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