TY - JOUR
T1 - Temperature stimuli-responsive nanoparticles from chitosan-graft-poly(N-vinylcaprolactam) as a drug delivery system
T2 - NA
AU - Fernández-Quiroz, Daniel
AU - Loya-Duarte, Jorge
AU - Silva-Campa, Erika
AU - Argüelles-Monal, Waldo
AU - Sarabia-Sainz, Andre
AU - Lucero-Acuña, Armando
AU - del Castillo-Castro, Teresa
AU - San Román, Julio
AU - Lizardi-Mendoza, Jaime
AU - Burgara-Estrella, Alexel J.
AU - Castaneda, Beatriz
AU - Soto-Puebla, Diego
AU - Pedroza-Montero, Martín
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This work describes the preparation of thermosensitive chitosan-graft-poly(N-vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N-vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug-association parameters, and the drug-loaded nanoparticles exhibited dose-dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti-cancer drug delivery system.
AB - This work describes the preparation of thermosensitive chitosan-graft-poly(N-vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N-vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug-association parameters, and the drug-loaded nanoparticles exhibited dose-dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti-cancer drug delivery system.
KW - biomaterials
KW - biomedical applications
KW - drug delivery systems
KW - nanostructured polymers
KW - stimuli-sensitive polymers
UR - http://www.scopus.com/inward/record.url?scp=85064523869&partnerID=8YFLogxK
U2 - 10.1002/app.47831
DO - 10.1002/app.47831
M3 - Artículo
AN - SCOPUS:85064523869
SN - 0021-8995
VL - 136
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 32
M1 - 47831
ER -