TY - JOUR
T1 - Two cases of hypergranular acute lymphoblastic leukemia
AU - Bolado-Martínez, Enrique
AU - Vivanco-Jiménez, Martha
AU - García-Ramírez, Francisco
AU - Ruiz-Reyes, Guillermo
AU - Ruiz-Argüelles, Alejandro
AU - Ruiz-Argüelles, Guillermo J.
PY - 1997/5
Y1 - 1997/5
N2 - Two patients with hypergranular acute lymphoblastic leukemia are presented: they represent 1.4% of patients with acute lymphoblastic leukemia studied and treated in a single institution in the past 12 years. This frequency is substantially lower than that reported in Caucasian populations. The blast cells of the patients disclosed an early-B phenotype, displaying CD45, CD10 and CD19 antigens. The cytoplasmic granules were positive for the PAS reaction. Both patients died early after starting treatment; a poor prognosis has been recorded previously for patients with this type of malignancy.
AB - Two patients with hypergranular acute lymphoblastic leukemia are presented: they represent 1.4% of patients with acute lymphoblastic leukemia studied and treated in a single institution in the past 12 years. This frequency is substantially lower than that reported in Caucasian populations. The blast cells of the patients disclosed an early-B phenotype, displaying CD45, CD10 and CD19 antigens. The cytoplasmic granules were positive for the PAS reaction. Both patients died early after starting treatment; a poor prognosis has been recorded previously for patients with this type of malignancy.
KW - Acute leukemia
KW - Early B leukemia
KW - Hypergranular leukemia
KW - Leukemia
KW - Lymphoblastic leukemia
UR - http://www.scopus.com/inward/record.url?scp=3242821561&partnerID=8YFLogxK
M3 - Artículo
SN - 0034-8376
VL - 49
SP - 227
EP - 230
JO - Revista de Investigacion Clinica
JF - Revista de Investigacion Clinica
IS - 3
ER -